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Charlie Sheen is an actor who takes drugs and used to be on Two and a Half men. He is mentioned in the Animaniacs segment Spellbound, in a spell Brain used throughout the episode. He is later mentioned by by Pinky, when Brain says that they are going to a place where females are paid to change constanly, in the episode Calvin Brain. Pinky responds by asking whether this place is Charlie Sheen's House.

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